High purity of 5-Fluorouracil in bulk supply Best price 51-21-8 CAS NO.51-21-8

Min.Order: 1 Kilogram
Payment Terms: T/T

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High purity 5-Fluorouracil
5-Fluorouracil in bulk supply
Best price 51-21-8

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ProName: High purity of 5-Fluorouracil in bulk ...
CasNo: 51-21-8
Molecular Formula: C4H3FN2O2
Appearance: White powder
Application: Anti tumor drug. For a variety of canc...
DeliveryTime: 5 days after payment
PackAge: 25kg firber drum
Port: shanghai
ProductionCapacity: 5 Metric Ton/Day
Purity: 99.0%min
Storage: dry and cool place
Transportation: by sea or air
LimitNum: 1 Kilogram
Grade: Industrial Grade

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High purity of 5-Fluorouracil in bulk supply Best price 51-21-8

5-Fluorouracil, 51-21-8

Molecular Weight: 130.077223 [g/mol]
Molecular Formula: C4H3FN2O2
XLogP3: -0.9
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 200-085-6
Melting Point: 282-286 °C (dec.)(lit.)
Surface Tension: 46.1 dyne/cm
Density: 1.53 g/cm3
Flash Point: 196.5 °C
Enthalpy of Vaporization: 67.78 kJ/mol
Boiling Point: 401.4 °C at 760 mmHg
Vapour Pressure: 5.13E-07 mmHg at 25°C
Water Solubility: 12.2 g/L 20 °C
Sensitive: Air Sensitive
Stability: Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.

Our Key Technology:

1. Low Temperature Reactions

2. Coupling Reactions

3. Fluorine Chemistry

4. Asymmetric HydrogenationNot dangerous goods

Our Advantages:

Rich experience in loading a great amount of containers in Chinese sea port;
Fast shipment by well-reputed shipping line;
Packaging with pallets according to buyers’ special request;
Cargoes together with container sales service available;
Rich experience in Korea,India &Europe export.

Synchem is dedicated to custom synthesis and manufacturing services for small molecules. We specialize in advanced fluorinating techno-logy, asymmetrical catalysis technology, and highly effective organic-metal catalysis technology.

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Available Date --- Expired Date

ISO

Transpacific Certifications Limited

ISO 9001:2008

Scope of Inspection: The Production, R&D,Pilot, Sales and Techology service of Liquid Crystal Intermediates, Liquid Crystal Monomer and Pharmaceutical Intermediates

2014/05/31---2017/05/30

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High purity of 5-Fluorouracil in bulk supply Best price 51-21-8

Product Name:	5-Fluorouracil
Synonyms:	[180]-5-Fluorouracil;2,4(1H,3H)-Pyrimidinedione, 5-fluoro-;2,4-dioxo-5-fluoropyrimidine;3h)-pyrimidinedione,5-fluoro-4(1h;5-faracil;5-Flouracyl;5-fluor-2,4(1h,3h)-pyrimidindion;5-Fluor-2,4-dihydroxypyrimidin
CAS:	51-21-8
MF:	C4H3FN2O2
MW:	130.08
EINECS:	200-085-6
Product Categories:	Pharmaceutical Raw Materials;PYRIMIDINE;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Phenylacetic acid;Tegafur Carmofur;Nucleotides and Nucleosides;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;Nucleotides;API's;Antitumour;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Inhibitor;Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;CARAC;Inhibitors;Anticancer
Mol File:	51-21-8.mol

Antimetabolite

5-fluorouracil is short for fluorouracil, and is pyrimidine antimetabolites, 5-fluorouracil as fluorouracil for pyrimidine antimetabolites, is currently clinically commonly used a chemotherapy drug, having effect on proliferation, can prevent the thymine formation, inhibition of DNA biosynthesis, thereby inhibiting the growth of cancer cells. Clinically, it is used to treat gastrointestinal tumors, such as stomach cancer, colon cancer, liver cancer and so on. In breast cancer, ovarian cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer and so on are also effective. The Swiss production of skin cancer treatment ointment containing 5% of the goods, mainly used for actinic keratoses and senile keratosis, precancerous dermatitis, single and multiple shallow table basal cell carcinoma, radioactive skin lesion of carcinoma and superficial basal cell carcinoma.

5-fluorouracil first changes for 5-Fluoro 2 deoxy urea pyrimidine nucleotides in vivo and inhibition of thymidylate synthase, blocking the transformation of urea pyrimidine deoxyribonucleotide thymidine, which affects DNA biosynthesis. At the same time, it can be incorporation into RNA by blocking urea ethyl pyridine and whey acid was incorporated into the RNA to direct inhibition of RNA synthesis.

This medicine is mainly in the liver metabolism, most of the decomposed into carbon dioxide discharged from breathing, rarely excreted from urine. After oral, absorption is different; vein after administration, concentrations in plasma quickly drop in two hours; static note within 30 minutes can arrive in cerebrospinal fluid (CSF) and maintain for 3 hours; continuous intravenous infusion toxicity is lighter than intravenous injection; vein to the drug's effect is compared with oral high. Toxicity of 5-fluorouracil on the proliferation is greater than non proliferating cells, but no obvious cell cycle specificity. Resistance to 5-FU can increase essential activity of enzyme missing or thymidylate synthetase activity.

5-Fluorouracil Uses

1. It is used for biochemical studies and antitumor drugs.

2. It is the anti tumor drug, also used for synthesis of flucytosine. 5-fluorouracil can be used in the study of rice in the biochemical studies, ear differentiation, genetic metabolic measurement, plant growth development research.

3. It is used for the digestive system cancer, head and neck cancer, gynecological cancer, lung cancer, liver cancer, treatment of bladder cancer and skin cancer.

4. Antimetabolite antitumor drugs.

5. Anti tumor drugs. There is a certain effect on a variety of tumors such as digestive tract cancer, breast cancer, ovarian cancer, chorionic epithelial cancer, cervical cancer, hepatocellular carcinoma, bladder cancer, skin cancer (topical), leukoplakia (topical) etc. Adverse reactions mainly are bone marrow transplantation, digestive tract reaction, serious person can have diarrhea, local injection site phlebitis, a few of which have nervous system reactions such as cerebellar degeneration and ataxia. The course of medication should strictly check the blood.

Why Choose China Synchem

1. Quality

Our products meet MSDS safe standard and we have ISO and other certificate so yan can get high quality products from our company.

2. Price

We are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.

3. Packing

We can do according to the customers' request.

4. Transport

The products can be transported by Courier, by air or by sea

5. Service

We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.

High purity of 5-Fluorouracil in bulk supply Best price 51-21-8 CAS NO.51-21-8

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