qualified of 5-Fluorouracil pharmaceutical intermediate 51-21-8 china CAS NO.51-21-8

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CAS NO.	51-21-8
Product Name	5-Fluorouracil
Synonyms	Ro-2-9757; Phtoruracil; Ulup; 2,4(1H,3H)-Pyrimidinedione,5-fluoro-; Phthoruracil; Uracil, 5-fluoro-; 5-Fluoro-2,4(1H, 3H)-pyrimidinedione; 2,4 (1H, 3H)-Pyrimidinedione, 5-fluoro-; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; Fluoroplex; 5-Fluoracyl; Efudex; Effluderm (free base); 5-Ftouracyl;   5-Fluoropyrimidine-2,4-dione;
Structure
Purity	99%
Molecular Formula	C4H3FN2O2
Molecular Weight	130.0772
Flash Point	196.5 °C
Refractive index	1.542
InChI	InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
Boiling Point	401.4 °C at 760 mmHg
Density	1.53 g/cm3
Melting Point	278-286℃
Storage Temperature	Store at 0-5℃

Introduction: 

Fluorouracil or 5-FU (trademarked as Adrucil(IV), Carac (topical), Efudex and Efudix (topical)) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition ofthymidylate synthase. It belongs to the family of drugs called the antimetabolites.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy.

Usage:

Fluorouracil (CAS NO.51-21-8) can be used in against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor. It can be used in colorectal cancer and pancreatic cancer,also it can be used for treating actinic (solar) keratoses and some types of basal cell carcinomas of the skin.

Fluorouracil has been given systemically for anal, breast, colorectal,oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). It has also been given topically for actinic keratoses, skin cancers and Bowen's disease.